Abstract:

Diabetes mellitus is a chronic metabolic disorder where the Beta-cells present on the islets of Langerhans of pancreas fail to produce enough insulin resulting in unstable blood glucose level that pave the way for insulin resistance by tissues. According to recent WHO (2016) report, 422 million populations were suffering from this metabolic disorder worldwide. Inflammatory mediators such as Alpha-glucosidase, Glucose Transporter Type-4, Sodium Glucose Transporter Type-2, Glucagon like peptide-1, 11 beta-Hydroxysteroid dehydrogenases, etc., are known to play an important role in pathogenesis of this disease and have been considered as potential therapeutic targets.